Visiting Turkey - Suggestions for holidays, trains, itineraries, day-trips, and sightseeing from someone who has lived and traveled extensively in Turkey
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It is possible to take a day trip from Istanbul to Ephesus in Turkey.
There are daily charter flights from Istanbul airport to Izmir, which is a short train or bus ride away from Ephesus.
Trains and buses from Izmir to Ephesus arrive at Selcuk, which is walking distance from the historic ruins of Ephesus.
Alternately, you can hire a taxi or hire a car to drive from Izmir to Ephesus.
There are plenty of package tours from Istanbul to Ephesus that will arrange a day trip with flights and airport transfers. This is one of the easiest and most convenient ways of visiting Ephesus on a day trip from Istanbul.
