Buses from Prague to Brno are a good alternative to taking a train or driving when you are visiting the Czech Republic.
The best services on this route are run by Student Agency. Student Agency buses are clean and offer free WiFi, movies, and air conditioning. Their coaches are bright yellow and hard to miss.
On this particular route, the company runs the “Fun & Relax Coach”, which features power outlets, individual touch screens, and complimentary newspapers, magazines, and refreshments.
Buses leave from the Florenc bus station in Prague (Metro: Florenc on Lines B and C). They arrive at a bus stop in Brno near the Grandhotel.
Coaches run daily from 00:30 until 21:00, so you can travel at any time that is convenient for you. Most services depart Prague every hour on the hour and half hour.
The driving time on buses from Prague to Brno ranges from 2 hours and 30 minutes to 2 hours and 45 minutes. The journey can take longer if there is traffic, so keep that in mind if you have a connection to make when you arrive.
The cost of a bus ticket to Brno is 8.20 euros one-way. You can buy them online to reserve a seat on the coach of your choice.